BAY 1251152| CAS 1610358-56-9|DC Chemicals

Cas No.:	1610358-56-9
Chemical Name:	(+)-BAY-1251152
Synonyms:	5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine;(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine;BCP29512;BCP33292;NSC802450;BAY1251152;(Inverted exclamation markA)-BAY-1251152;(+)-BAY-1251152
SMILES:	S(C)(CC1C=CN=C(C=1)NC1C=C(C(=CN=1)F)C1C=CC(=CC=1OC)F)(=N)=O
Formula:	C₁₉H₁₈F₂N₄O₂S
M.Wt:	404.4336
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM, displays> 50-fold selectivity against other CDKs;exhibits broad anti-proliferative activity against a panel of tumour cell lines with sub-micromolar IC50 values; demonstrates excellent efficacy in xenograft models (e.g. MOLM13) in mice and rats.Blood CancerPhase 1 Clinical

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