AKB-9778|CAS 1008510-37-9|DC Chemicals

Cas No.:	1008510-37-9
Chemical Name:	AKB-9778
Synonyms:	AKB 9778;AKB9778
SMILES:	O=S(O)(NC1=CC=C(C[C@H](NC([C@@H](NC(OC)=O)CC2=CC=CC=C2)=O)C3=CSC(C4=CC=CS4)=N3)C=C1)=O
Formula:	C₂₆H₂₆N₄O₆S₃
M.Wt:	586.696
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AKB-9778 is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with IC50 of 17 pM; shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (IC50=100 pM); activates TIE2, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK; blocks VEGF-induced leakage from dermal and retinal vessels and prevents exudative retinal detachments in double-transgenic mice.DiabetesPhase 2 Clinical

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