BCI-215|CAS 1245792-67-9|DC Chemicals

Cas No.:	1245792-67-9
Chemical Name:	(E)-2-benzylidene-5-bromo-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
Synonyms:	BCI215;BCI 215
SMILES:	C(=O)1C2=C(C=C(Br)C=C2)C(NC2CCCCC2)/C/1=C\C1=CC=CC=C1
Formula:	C₂₂H₂₂BrNO
M.Wt:	396.328

Description:

BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor; restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells; inhibits cell motility, causes apoptosis but not primary necrosis, and sensitizes cells to lymphokine-activated killer cell activity in MDA-MB-231 human breast cancer cells; induces rapid and sustained phosphorylation of ERK, p38 and JNK, also hyperactivates MKK4/SEK1; causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling.

References:

References 1. Kaltenmeier CT, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50. View Related Products by Target Protein Phosphatase/PTP

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