DJ101|DJ-101|CAS 1803242-21-8|tubulin inhibitor

Cas No.:	1803242-21-8
Chemical Name:	2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine
Synonyms:	DJ-101;DJ 101
SMILES:	COC1=C(OC)C(OC)=CC(C2=NC=CC3=C2N=C(C4=CC=CC5=C4C=CN5)N3)=C1
Formula:	C₂₃H₂₀N₄O₃
M.Wt:	400.438
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors; demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM, disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration; inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model.

References:

References 1. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277. View Related Products by Target Microtubule/Tubulin

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