BTZO-1|BTZO 1|CAS 99420-15-2|DC Chemicals

Cas No.:	99420-15-2
Chemical Name:	2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Synonyms:	BTZO-1\|BTZO 1
SMILES:	C1=CC=C(C2=NC(=O)C3=CC=CC=C3S2)N=C1
Formula:	C₁₃H₈N₂Os
M.Wt:	240.28
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].
Target:	Kd:68.6 nM (Macrophage migration inhibitory factor)[1]
In Vitro:	BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1]. Cell Viability Assay[1] Cell Line: Primary Neonatal Rat Cardiomyocytes Concentration: 0-330 nM Incubation Time: 24 hours Result: Suppressed serum deprivation or DOX-induced cell death.
References:	[1]. Kimura H, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.Chem Biol. 2010 Dec 22;17(12):1282-94.

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