SMAP| CAS 1809427-18-6

Cas No.:	1809427-18-6
Chemical Name:	N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
Synonyms:	SMAP;s8774;L2J;N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
SMILES:	S(C1C=CC(=CC=1)OC(F)(F)F)(N[C@@H]1CCC[C@@H]([C@H]1O)N1C2C=CC=CC=2OC2C=CC=CC1=2)(=O)=O
Formula:	C₂₅H₂₃F₃N₂O₅S
M.Wt:	520.52073597908
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.
References:	References 1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090. 2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. View Related Products by Target Protein Phosphatase/PTP

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