Bax inhibitor peptide V5| CAS 579492-81-2

Cas No.:	579492-81-2
Chemical Name:	L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-
Synonyms:	Val-Pro-Met-Leu-Lys;BIP-V5
SMILES:	O=C([C@H](CCC1)N1C([C@@H](N)C(C)C)=O)N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCCN)=O)=O
Formula:	C₂₇H₅₀N₆O₆S
M.Wt:	586.7875
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
In Vivo:	V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].
In Vitro:	Bax inhibitor peptide V5 (0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].

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