Corticotropin-releasing factor (ovine)| CAS 79804-71-0

Cas No.:	79804-71-0
Chemical Name:	Corticorelin ovine triflutate
Synonyms:	Ovine CRF;Ovine corticotropin-releasing factor;Corticotropin-releasing factor (ovine);corticotropin-releasing hormone (ovine);CRF (ovine);CRF (ovine) Trifluoroacetate;CRF (ovine), Corticorelin (ovine);Corticorelin;CRF(Ovine)Trifluoroacetate;Corticorelin ovine;Ovine CRH;Ovine CRF 41;Ovine ACTH releasing factor;Corticotropin-releasing factor (sheep);Corticotropin-releasing factor (sheep hypothalamus);Corticorelin ovine triflutate;Amunine;Amunin;oCRH;Ovine corticotropin-releasing hormone;Corticorelin triflutate;Sheep corticotropin-releasing factor;Corticotropin-releasing hormone, ovin
SMILES:	S(C)CCC(C(NC(C(NC(C(NC(C)C(NC(CC(=O)O)C(NC(CCC(N)=O)C(NC(C(NC(C)C(NC(C(NC(C(NC(C)C(NC(CC1=CN=CN1)C(NC(CO)C(NC(CC(N)=O)C(NC(CCCNC(=N)N)C(NC(C(NC(C(NC(C(NC(CC(=O)O)C(NC(C(NC(C(N)=O)C)=O)C(C)CC)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCCN)=O)=O)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CCCCN)=O)C(C)O)=O)NC(C(CCC(=O)O)NC(C(CC(C)C)NC(C(C(C)C)NC(C(CCC(=O)O)NC(C(CCCNC(=N)N)NC(C(CC(C)C)NC(C(CC(C)C)NC(C(CC1=CN=CN1)NC(C(CC1C=CC=CC=1)NC(C(C(C)O)NC(C(CC(C)C)NC(C(CC(=O)O)NC(C(CC(C)C)NC(C(CO)NC(C(C(C)CC)NC(C1CCCN1C(C1CCCN1C(C(CCC(=O)O)NC(C(CCC(N)=O)NC(C(CO)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula:	C₂₀₅H₃₃₉N₅₉O₆₃S
M.Wt:	4670.30770611763
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Corticotropin-releasing factor (ovine) is a preferential CRF1 receptor agonist.
Target:	CRF1 receptor[1].
In Vivo:	Corticotropin-releasing factor (ovine) (Ovine CRF: 0.1-2.5 nM) stimulates corticotropin release by pituitaries of Wistar rats and this effect is augmented two- to three fold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml) [2]. oCRF (10 μg) suppresses 6-h intake of cafeteria diet-fed rats without regard to macronutrient composition. Rather, oCRF most potently suppresses intake of preferred food items[1].
In Vitro:	Corticotropin-releasing factor (ovine), a preferential CRF1 receptor agonist, shows almost 200-fold greater affinity for the CRF1 than CRF2 receptor[1].
References:	[1]. Eric P. Zorrilla et al. Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1027-1034; [2]. Antoni FA et al. Oxytocin as well as vasopressin potentiate ovine CRF in vitro. Peptides. 1983 Jul-Aug;4(4):411-5.

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Corticorelin ovine triflutate