BAMB-4(ITPKA-IN-C14)|CAS 891025-25-5|DC Chemicals

Cas No.:	891025-25-5
Chemical Name:	Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl-
Synonyms:	ITPKA-IN-C14,BAMB-4,BAMB4,BAMB 4
SMILES:	O=C(C1=CC=C(C)C=C1)NC2=NOC3=CC=CC=C23
Formula:	C₁₅H₁₂N₂O₂
M.Wt:	252.268

Description:	BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.BAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy.
Target:	IC50 value: 37 uM Target: ITPKA inhibitor
References:	[1]. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.

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