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(±)-BAY-1251152

  Cat. No.:  DC60039   Featured
Chemical Structure
1610358-53-6
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More than 5000 active chemicals with high quality for research!
Field of application
AY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1610358-53-6
Chemical Name: BAY-1251152 racemate
Synonyms: (±)-BAY-1251152;5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine;(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine;BAY1251152;BCP29512;BCP33292;NSC802450;(±)-Enitociclib
SMILES: S(C)(CC1C=CN=C(C=1)NC1C=C(C(=CN=1)F)C1C=CC(=CC=1OC)F)(=N)=O
Formula: C19H18F2N4O2S
M.Wt: 404.436
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
References: [1]. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984
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