Val-Lys(Boc)-PAB|cas 1432969-86-2|DC Chemicals

Cas No.:	1432969-86-2
Chemical Name:	tert-butyl ((S)-5-((S)-2-amino-3-methylbutanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate
Synonyms:	Val-Lys(Boc)-PAB;
SMILES:	CC(C)(OC(NCCCC[C@@H](C(NC1=CC=C(CO)C=C1)=O)NC([C@H](C(C)C)N)=O)=O)C
Formula:	C₂₃H₃₈N₄O₅
M.Wt:	450.58
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Val-Lys(Boc)-PAB is a ADC linker. Val-Lys(Boc)-PAB was used to prepare camptothecin peptide conjugates as antitumor agents (WO 2019195665). It was used as a non-linear self-immolative linker for reducing hydrophobicity of antibody-drug conjugates for cancer therapy (WO 2018069375).

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