M1001|CAS 874590-32-6|DC Chemicals

Cas No.:	874590-32-6
Chemical Name:	N-[2-(Pyrrolidin-1-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
Synonyms:	M1001;STK869139;ST51040632;3-[(2-pyrrolidinylphenyl)amino]benzo[d]1,2-thiazoline-1,1-dione;N-[2-(pyrrolidin-1-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide;N-(2-pyrrolidin-1-ylphenyl)-1,2-benzisothiazol-3-amine 1,1-dioxide
SMILES:	S1(C2=C([H])C([H])=C([H])C([H])=C2C(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(=O)=O
Formula:	C₁₇H₁₇N₃O₂S
M.Wt:	327.400782346725
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	M1001 is a weak agonist of HIF-2α, directly binds to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 enhances the stabilities of HIF-2α-ARNT complex[1].
Target:	Kd: 667 nM (HIF-2α)[1]
References:	[1]. Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25.

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