HIV-1 integrase inhibitor 8|cas 1568-80-5|DC Chemicals

Cas No.:	1568-80-5
Chemical Name:	1,1,1',1'-Tetramethyl-3,3'-spirobi[3a,7a-dihydro-2H-indene]-5,5'-diol
Synonyms:	1,1'-Spirobi[1H-indene]-6,6'-diol,2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-;2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol;5-PHENYL-2,2'-BIPYRIDINE;SPIROBIINDANE;2,2',3,3'-TETRAHYDRO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBI-1H-INDENE- 6,6'-DIOL;tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol;Spiro Biindane Bisphenol;BDBM176762;US9688816, 5;1,1,1',1'-Tetramethyl-3,3'-spirobi[3a,7a-dihydro-2H-indene]-5,5'-diol
SMILES:	O([H])C1C([H])=C([H])C2([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3(C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C4([H])C([H])=C([H])C(=C([H])C34[H])O[H])C2([H])C=1[H]
Formula:	C₂₁H₂₈O₂
M.Wt:	312.4458
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].
In Vitro:	HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1]. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].
References:	[1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem

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