D-3263|D3263||Trp-p8 agonist

Cas No.:	947257-66-1
Chemical Name:	D-3263 free base
Synonyms:	D3263,D 3263,D-3263
SMILES:	O=C1N(CCN)C2C(=CC=C(C=2)OC)N1C(=O)[C@H]1C[C@@H](C)CC[C@@H]1C(C)C
Formula:	C₂₁H₃₁N₃O₃
M.Wt:	373.497
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:	D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
In Vivo:	D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].
In Vitro:	D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].
References:	[1]. David Duncan, et al. PRECLINICAL EVALUATION OF THE TRPM8 ION CHANNEL AGONIST D-3263 FOR BENIGN PROSTATIC HYPERPLASIA. THE JOURNAL OF UROLOGY, Vol. 181, No. 4, Supplement, Tuesday, April 28, 2009

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