D-64131|cas 74588-78-6|DC Chemicals

Cas No.:	74588-78-6
Chemical Name:	(5-Methoxy-1H-indol-2-yl)-phenylmethanone
Synonyms:	Methanone,(5-methoxy-1H-indol-2-yl)phenyl-;(5-methoxy-1H-indol-2-yl)-phenylmethanone;D 64131;D-6413;D-64131;5-methoxy-1H-2-indolylphenyl-1-methanone;5-methoxy-2-benzoylindole;Tocris-1643;(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE;(5-Methoxy-1H-indol-2-yl)(phenyl)methanone;(5-Methoxy-1H-indol-2-yl)-phenyl-methanone;2-Benzoyl-5-methoxyindole;ICMIJSRDISNKOC-UHFFFAOYSA-N;HMS3676P03;HMS3268K07;BCP06496;BS0058;BDBM50107658;3570AH;API0002200
SMILES:	O(C([H])([H])[H])C1C([H])=C([H])C2=C(C=1[H])C([H])=C(C(C1C([H])=C([H])C([H])=C([H])C=1[H])=O)N2[H]
Formula:	C₁₆H₁₃NO₂
M.Wt:	251.2799
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin.

References:

[1]. Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553. [2]. Bacher, G.; Beckers, T.; Emig, P. et al. New small-molecule tubulin inhibitors. Pure and Applied Chemistry (2001), 73(9), 1459-1464. [3]. Beckers, Thomas; Reissmann, Thomas; Schmidt, Mathias et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119.

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