EMA400|cas 152362-51-1|DC Chemicals

Cas No.:	152362-51-1
Chemical Name:	2-(2,2-Diphenylacetyl)-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Synonyms:	EMA400;EMA 400;BCP24001;BCP29286;AK678945;L009862;2-(2,2-Diphenylacetyl)-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
SMILES:	O(CC1C=CC=CC=1)C1=C(C=CC2=C1CC(C(=O)O)N(C(C(C1C=CC=CC=1)C1C=CC=CC=1)=O)C2)OC
Formula:	C₃₂H₂₉NO₅
M.Wt:	507.576369047165
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

EMA400 is a potent and highly selective AT2R antagonist.

In Vitro:

EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. target: AT2R In vivo: AngII induces p38, p42/p44 mitogen activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons that is blocked by EMA401. Inhibits capsaicin responses in cultured hDRG neurons.

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