FLLL32|FLLL32,FLLL-32,FLLL 32|Purchase|DC CHEM

Cas No.:	1226895-15-3
Chemical Name:	FLLL32,FLLL-32,FLLL 32
Synonyms:	FLLL32,FLLL-32,FLLL 32
SMILES:	O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3
Formula:	C₂₈H₃₂O₆
M.Wt:	464.55
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].
In Vitro:	FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].

Cat. No.	Product name	Field of application
DC46604	CMD178	CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. CMD178 also is an inhibitor of STAT5 and inhibit Treg cell development.
DC10139	Stat5 Inhibitor(STAT5-IN-1)	Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain.
DC10105	SH5-07	SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay.
DC7983	SH-4-54	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
DC9691	Piperlongumine	Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53.
DC8474	Napabucasin (BBI608)	Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.
DC10555	inS3-54A18	inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
DC7751	FLLL32	FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor.
DC10864	C188-9	C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
DC11420	AS-1517499	AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.