Felbamate|cas 25451-15-4, 1177501-39-1 (H2O)|supplier DC Chemicals

Cas No.:	25451-15-4
Chemical Name:	1,3-Propanediol, 2-phenyl-, dicarbamate (8CI,9CI); Carbamic acid, 2-phenyltrimethylene ester
Synonyms:	Felbatol
SMILES:	NC(OCC(C1=CC=CC=C1)COC(N)=O)=O
Formula:	C₁₁H₁₄N₂O₄
M.Wt:	238.24
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Felbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.

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