GCN2-IN-1|A92|cas 1448693-69-3|DC Chemicals

Cas No.:	1448693-69-3
Chemical Name:	N-[3-(2H-indazol-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-1-(oxan-4-yl)-1H-pyrazol-4-amine
Synonyms:	GCN2-IN-1
SMILES:	C1(NC2=CN(C3CCOCC3)N=C2)=NC=C(N=NN4C5=CC6=C(C=C5)C=NN6)C4=N1
Formula:	C₁₉N₁₀OH₁₈
M.Wt:	402.4126
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.
In Vitro:	GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for the treatment of cancer[1].
References:	[1]. Brazeau JF, et al. Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3.

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