GSK2983559|CAS 1579965-12-0|DC Chemicals

Cas No.:	1579965-12-0
Chemical Name:	2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate
Synonyms:	GSK-2983559,GSK 2983559 GSK2983559
SMILES:	CC(S(=O)(=O)C1=CC2=C(NC3C=CC4SC=NC=4C=3)N=CN=C2C=C1OCCOP(=O)(O)O)(C)C
Formula:	C₂₁H₂₃N₄O₇PS₂
M.Wt:	538.53
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication:	[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Infl

Description:

GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

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