GSK9311|GSK-9311|BRPF bromodomain inhibitor

Cas No.:	1923851-49-3
Synonyms:	GSK9311,GSK-9311,GSK 9311
SMILES:	O=C(N(CC)C1=C(N2[C@H](C)CNCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Formula:	C₂₄H₃₁N₅O₃
M.Wt:	437.24
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively.
Target:	IC50: 6.0 (BRPF1), 4.3 (BRPF2)[1]
In Vitro:	GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].
References:	[1]. Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

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