GW-1100|cas 306974-70-9|DC Chemicals

Cas No.:	306974-70-9
Synonyms:	GW1100;GW1100
SMILES:	O=C1C(CC2=CN=C(N=C2)OCC)=CN(C(SCC3=CC=C(C=C3)F)=N1)C4=CC=C(C(OCC)=O)C=C4
Formula:	C₂₇H₂₅FN₄O₄S
M.Wt:	520.5752
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99. GPR40 is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99. However at concentrations up to 10 μM, GW 1100 has no effect on GPR120-mediated stimulation of intracellular Ca2+ release induced by either GW 9508 or linoleic acid. In the MIN6 mouse insulinoma cell line, 1 μM GW 1100 inhibits the potentiating effects of GW 9508 and linoleic acid on glucose-stimulated insulin secretion.

Cat. No.	Product name	Field of application
DC9458	GW-1100	GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
DC11143	GPR40 AgoPAM AP5	GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
DC11623	GPR120 agonist 4x	A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.
DC11680	LY3104607	A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
DC11682	LY2922083	A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
DC11683	LY2881835	A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
DC11697	AM-1638	A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.
DC11994	ZQ-16	A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.