ICA 110381 (Compound 16) |cas 325457-99-6

Cas No.:	325457-99-6
Synonyms:	ICA110381,ICA-110381,ICA 110381,CAS 325457-99-6
SMILES:	O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2
Formula:	C₁₂H₈Cl₂N₂O
M.Wt:	267.11
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
Target:	EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1]
References:	[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

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