ID-8(ID8)|cas 147591-46-6|DC Chemicals

Cas No.:	147591-46-6
Chemical Name:	ID8
Synonyms:	1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol;ID-8;ID 8;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8;ID8
SMILES:	[2H]I
Formula:	HI
M.Wt:	128.918574094772
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:	ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
Target:	DYRK
In Vitro:	the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2].
References:	[1]. Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1(1): p. 18-28. [2]. Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72(5): p. 1242-8.

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