IKK-16(IKK16)|cas 1186195-62-9|DC Chemicals

Cas No.:	1186195-62-9
Chemical Name:	IKK 16
Synonyms:	IKK 16;IKK-16 (hydrochloride) NEW;IKK-16 Hydrochloride
SMILES:	Cl.C1CCN(C2CCN(C(C3=CC=C(NC4N=CC=C(C5=CC6=CC=CC=C6S5)N=4)C=C3)=O)CC2)C1
Formula:	C₂₈H₃₀ClN₅Os
M.Wt:	520.088703632355
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively[1]. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM[2].
References:	[1]. Waelchli R, et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. [2]. Hermanson SB, et al. Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS One. 2012;7(8):e43580.

Cat. No.	Product name	Field of application
DC8761	BMS-345541	BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
DC7759	WS6	WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
DC7760	WS3	WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).
DC8065	LY2409881 trihydrochloride	LY2409881 is a novel inhibitor of IκB kinase β (IKK2).
DC8770	IMD-0354	IMD-0354 is a synthetic selective NF-kB inhibitor.
DC7802	IKK(epsilon)-IN-1 (IKKE-IN-1)	IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
DC9485	IKK-16(free base)	IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
DC7158	IKK-16 HCl	IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

IKK-16 HCl