(R)-IMPP|PCSK9 inhibitor|cas 2133832-83-2|DC Chemicals

Cas No.:	2133832-83-2
Chemical Name:	R-IMPP
Synonyms:	R-IMPP;Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-
SMILES:	C1(CCC(N(C2C3=C(C=CC=C3)C=CN=2)[C@@H]2CCCNC2)=O)=CC=C(OC)C=C1
Formula:	C₂₄H₂₇N₃O₂
M.Wt:	389.5
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	R-IMPP is an inhibitor of PCSK9 secretion.
In Vitro:	R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].
References:	[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371

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