Isoscopoletin|cas 776-86-3|DC Chemicals

Cas No.:	776-86-3
Chemical Name:	Isoscopoletin
Synonyms:	6-Hydroxy-7-methoxy-2H-chromen-2-one;6-Hydroxy-7-methoxycoumarin;6-Hydroxy-7-methoxy-2-benzopyrone;Isoscopoletin;6-hydroxy-7-methoxychromen-2-one;6-HYDROXY-7-METHYL COUMARIN (ISOSCOPOLETIN);ISOSCOPOLETIN(P);ISOSCOPOLETIN(RG);ISOSCOPOLETIN(RG) PrintBack;[ "" ];7-Methoxyesculetin;Isoscopoletine;2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-;6-hydroxy-7-methoxy-chromen-2-one;iso-scopoletin;Esculetin 7-methyl ether;Esculetin, 7-methyl ether;6-Hydroxy-7-methylcoumarin;SYTYLPHCLSSCOJ-UHFFFAOYSA-N;ZIN
SMILES:	O1C(C([H])=C([H])C2=C([H])C(=C(C([H])=C12)OC([H])([H])[H])O[H])=O
Formula:	C₁₀H₈O₄
M.Wt:	192.1681
Purity:	>98%, Standard References Grade
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

References:

[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4. [2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

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