LolCDE-IN-1|CAS 1639933-78-0|DC Chemicals

Cas No.:	1639933-78-0
Chemical Name:	LolCDE-IN-1
SMILES:	FC1C=CC(COC2C=CC=C(C3C(C4C=CN=CC=4)=CNN=3)C=2)=CC=1
Formula:	C₂₁H₁₆FN₃O
M.Wt:	345.37
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Nayar AS, et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

Description:	LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].
Target:	Bacterial
In Vitro:	LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane[1]. LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml[1]. LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane[1].
References:	[1]. Nayar AS, et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

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