MF-438|MF438|CAS 921605-87-0|DC Chemicals

Cas No.:	921605-87-0
Chemical Name:	2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
Synonyms:	MF-438; MF 438; MF438.
SMILES:	FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F
Formula:	C₁₉H₁₈F₃N₅Os
M.Wt:	421.4422
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

Description:	MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].
Target:	EC50: 2.3 nM (rSCD1)[1]
In Vivo:	MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].
References:	[1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

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