MK-28|CAS 864388-65-8|DC Chemicals

Cas No.:	864388-65-8
Chemical Name:	MK-28
SMILES:	OC1=CC=C(C=C1O)/C=N/N(C2=NC(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2)C
Formula:	C₂₄H₂₀N₄O₂
M.Wt:	396.44
Sotrage:	Powder-20°C3 years4°C2 yearsIn solvent-80°C 6 months-20°C1 month

Cat. No.	Product name	Field of application
DC41027	MK-28	MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.
DC28778	PERK-IN-2	PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM.
DC28683	PERK-IN-3	PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM.
DC28501	AMG PERK 44	AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively.
DC12283	CCT020312	CCT020312 is capable of delivering potent, and eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3) selective, proliferation control and also is an activator of RNA-like endoplasmic reticulum kinase (PERK).