ML216|ML 216; ML-216|Purchase|DC CHEM

Cas No.:	1430213-30-1
Synonyms:	ML 216; ML-216; CID-49852229; CID49852229; CID 49852229
SMILES:	N(C1=CC=C(F)C(C(F)(F)F)=C1)C(NC1=NN=C(C2C=CN=CC=2)S1)=O
Formula:	C₁₅H₉F₄N₅Os
M.Wt:	383.32
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.ML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM.
Target:	IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM) Target: BLM helicase inhibitor
References:	[1]. Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62.

Cat. No.	Product name	Field of application
DC10375	YU238259	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
DC7771	ML216	ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.
DC9697	HUHS015	HUHS015 is a prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) inhibitor.
DC10026	B02	B02 is a cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM).