MYC inhibitor DC-34|DC-34|CAS 1966107-70-9

Cas No.:	1966107-70-9
Chemical Name:	4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-3-carboxamide
Synonyms:	DC34,DC 34
SMILES:	O1C2=CC=C(O)C(CN3CCCCCC3)=C2C(C(NC2=CC=C(C(F)(F)F)C=C2)=O)=C1C
Formula:	C₂₄H₂₅F₃N₂O₃
M.Wt:	446.47
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM; does not transcriptionally downregulate several other G4-dependent genes to the same extent; binds independently to the MYC G4 3'and 5' ends, demonstrates cytotoxicity in L363 MM cells with IC50 of 3.5 uM.

References:

References 1. Calabrese DR, et al. Nat Commun. 2018 Oct 12;9(1):4229. 2. Felsenstein KM, et al. ACS Chem Biol. 2016 Jan 15;11(1):139-48. View Related Products by Target c-Myc

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