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| Cas No.: | 1286281-32-0 |
| Chemical Name: | Amino-PEG6-t-butyl ester |
| Synonyms: | Amino-PEG6-t-butyl ester;tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate |
| SMILES: | CC(OC(CCOCCOCCOCCOCCOCCOCCN)=O)(C)C |
| Formula: | C19H39NO8 |
| M.Wt: | 409.514867067337 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Target: | PEGs Alkyl/ether Non-cleavable |
| In Vitro: | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References: | [1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295. [2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1. |