NSC228155 |EGFR activator

Cas No.:	113104-25-9
Synonyms:	NSC228155,NSC-228155,NSC 228155
SMILES:	O=[N+](C1=CC=C(SC2=CC=CC=[N+]2[O-])C3=NON=C31)[O-]
Formula:	C₁₁H₆N₄O₄S
M.Wt:	290.25
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].
Target:	IC50: 0.36 μM (KIX-KID)[1]
In Vitro:	NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with an IC50 of 2.09 and 6.14 μM, respectively[1].
References:	[1]. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.

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