ONX-0914 (ONX0914，PR-957|supplier DC Chemicals

Cas No.:	960374-59-8
Chemical Name:	(S)-3-(4-methoxyphenyl)-N-((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
Synonyms:	ONX 0914; ONX0914; ONX-0914; PR-957
SMILES:	C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4
Formula:	C₃₁H₄₀N₄O₇
M.Wt:	580.28
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Description of ONX 0914: ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity For the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-23. In preclinical models of rhematoid arthritis and lupus, ONX 0914 blocked progression of these diseases at well-tolerated doses. Preclinical studies are underway to evaluate the potential of ONX 0914 in the treatment of a range of autoimmune disorders. For the detailed information about the solubility of ONX-0914 in water, the solubility of ONX-0914 in DMSO, the solubility of ONX-0914 in PBS buffer, the animal experiment（test） of ONX-0914,the in vivo,in vitro and clinical trial test of ONX-0914,the cell experiment（test） of ONX-0914,the IC50, EC50 and Affinity of ONX-0914, please contact DC Chemicals.

Cat. No.	Product name	Field of application
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DC10304	RA190	RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
DC4243	ONX-0914	ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus.
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DC78938	Carmaphycin-17	Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research.
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