PF-06885249|CAS 1467059-70-6|DC Chemicals

Cas No.:	1467059-70-6
Chemical Name:	6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
Synonyms:	PF06885249;PF 06885249
SMILES:	N1C2=C(C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)C(C(O)=O)=C1
Formula:	C₁₇H₁₆ClN₃O₃
M.Wt:	345.783
Purity:	>98%
Publication:	Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK

Description:	PF-249 is a potent, selective AMPK β1-containing complexes activator; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 296 nM, potently inhibits de novo lipogenesis (IC50=15 nM) in primary rat hepatocytes.
References:	Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK

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PF-06885249(PF249)