PR-619|cas 2645-32-1|DC Chemicals|Price|Buy

Cas No.:	2645-32-1
Chemical Name:	PR 619; PR619
Synonyms:	PR 619; PR619
SMILES:	C1=C(C(=NC(=C1SC#N)N)N)SC#N
Formula:	C₇H₅N₅S₂
M.Wt:	223.28
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PR-619 is a broad-range DUB inhibitor with EC50 of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively.

In Vitro:

PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. In PR-619 treated cells, channel degradation is significantly inhibited with 87±1% of KCa3.1 still remaining after 24 hrs (n=3; P<0.05)[2]. Cell viability is determined by MTT assay and revealed that PR-619 exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM[3].

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