Prostaglandin D2 (PGD2) | cas 41598-07-6| DC Chemicals

Cas No.:	41598-07-6
Chemical Name:	Prosta-5,13-dien-1-oicacid, 9,15-dihydroxy-11-oxo-, (5Z,9a,13E,15S)-
Synonyms:	Prosta-5,13-dien-1-oicacid, 9,15-dihydroxy-11-oxo-, (5Z,9a,13E,15S)-;Prostaglandin D2;PGD2 (Prostaglandin D2);Prostaglandin D2 Lipid Maps MS Standard;(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid;PGD2
SMILES:	OC1CC(=O)C(/C=C/C(O)CCCCC)C1C/C=C/CCCC(O)=O
Formula:	C₂₀H₃₂O₅
M.Wt:	352.465086936951
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
Target:	Human Endogenous Metabolite
In Vivo:	Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles.
References:	[1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729.

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