Pyridostatin(RR 82)|cas 1085412-37-8|supplier|DC Chemicals

Cas No.:	1085412-37-8
Chemical Name:	4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide
Synonyms:	RR82,RR-82
SMILES:	C(C(NC1C=C(OCCN)C2C(N=1)=CC=CC=2)=O)1=NC(C(NC2C=C(OCCN)C3C(N=2)=CC=CC=3)=O)=CC(OCCN)=C1.C(O)(=O)C(F)(F)F
Formula:	C₃₁H₃₂N₈O₅^.XC₂Hf₃O₂
M.Wt:	596.63(free base)
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.
In Vitro:	Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].

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Pyridostatin trifluoroacetate salt