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RU-SKI 43 (hydrochloride)

Cat. No.: DC9464

Chemical Structure

1043797-53-0

For research use only. We do not sell to patients.

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Field of application

RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	1043797-53-0
Synonyms:	RU-SKI43 hydrochloride;Hhat Inhibitor
SMILES:	O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3.Cl
Formula:	C₂₂H₃₁ClN₂O₂S
M.Wt:	423.0117
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

Cat. No.	Product name	Field of application
DC9464	RU-SKI 43 (hydrochloride)	RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.