(Rac)-Benpyrine|CAS 1333714-43-4|DC Chemicals

Cas No.:	1333714-43-4
Chemical Name:	(Rac)-Benpyrine
SMILES:	O=C1N(CC2=CC=CC=C2)CC(NC3=C4N=CNC4=NC=N3)C1
Formula:	C₁₆H₁₆N₆O
M.Wt:	308.34
Purity:	>98%
Sotrage:	4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Description:	(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
Target:	TNF-α
In Vivo:	(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1]. Animal Model: Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] Dosage: 25 mg/kg, 50 mg/kg Administration: Oral gavage; daily; for 3 weeks Result: The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
In Vitro:	(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].
References:	[1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.

Cat. No.	Product name	Field of application
DC40738	(Rac)-Benpyrine	(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research.