SEP-0372814 cas 1516895-53-6 from DC Chemicals

Cas No.:	1516895-53-6
Synonyms:	SEP 0372814，SEP0372814
SMILES:	CC1=CN=C(C2=NC(=NN12)[C@@H]3C[C@H]3C4=C(N5C=CC6=C(C5=N4)C=CC=N6)C)C
Formula:	C₂₁H₂₁N₇
M.Wt:	371.19
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SEP-0372814 is a potent PDE10 inhibitor.

Cat. No.	Product name	Field of application
DC9847	Vesnarinone(OPC8212)	Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.
DC7945	TAK-063	TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
DC9779	Sildenafil citrate	Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
DC8048	SEP-0372814	SEP-0372814 is a potent PDE10 inhibitor.
DC4146	Roflumilast	Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.
DC7247	PF-8380	PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM.
DC7201	PF-2545920(MP-10)	PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.
DC11367	PF-04447943	PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.
DC9577	Olprinone (Hydrochloride)	Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor.
DC7676	IBMX(NSC165960; SC2964)	IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist.