SM-102|Ionizable Lipid for LNP

Cas No.:	2089251-47-6
Chemical Name:	8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester
Synonyms:	SM-102;SM 102;SM102
SMILES:	O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O
Formula:	C₄₄H₈₇NO₅
M.Wt:	710.1653
Purity:	>99%
Sotrage:	-20°C, protect from light
Publication:	1. Sabnis, S., Kumarasinghe , E.S., Salerno, T., et al. A novel amino lipid series for mRNA delivery: Improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol. Ther. 26(6), 1509-1519 (2018).

Cat. No.	Product name	Field of application
DC52025	SM-102	SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles.Administration of luciferase mRNA in SM-102-containing lipid nanoparticles induces hepatic luciferase expression in mice. Formulations containing SM-102 have been used in the development of lipid nanoparticles for delivery of mRNA-based vaccines.
DC10800	DLin-MC3-DMA	D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA.