SPI 112 |cas 1051387-90-6

Cas No.:	1051387-90-6
Chemical Name:	SPI-112;SPI112
Synonyms:	SPI-112;SPI112
SMILES:	C1=CC(S(NCC2=CC=C(F)C=C2)(=O)=O)=CC2/C(=N/NC3=CC=CC(C(=O)O)=C3)/C(=O)NC1=2
Formula:	C₂₂H₁₇FN₄O₅S
M.Wt:	468.45
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].

In Vitro:

SPI-112 has a polar -NO2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable[1]. In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant KD of 1.30 µM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (Ki of 0.8 µM), suggesting that SPI-112 interacts with the catalytic site of SHP2[1].

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