Saccharin 1-methylimidazole (SMI)|cas 482333-74-4|DC Chemicals

Cas No.:	482333-74-4
Chemical Name:	Saccharin 1-methylimidazole
SMILES:	C1=CC=CC2S(=O)(=O)N=C([O-])C1=2.C1[NH+](C)C=CN=1
Formula:	C₁₁H₁₁N₃O₃S
M.Wt:	265.287
Purity:	>98%

Description:	Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.
Target:	Target: DNA/RNA Synthesis[1]
In Vitro:	Exposure to certain concentrations of the entirely different promoters phenobarbital and the calcium and sodium salts of saccharin (22, 23, 25, 29, 38) stimulates calcium-deprived T51B cells to initiate DNA synthesis as rapidly and as effectively, or nearly as effectively, as raising the extracellular calcium concentration to 1.25 mM[1].
References:	[1]. Boynton AL, et al. Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1980 Dec;40(12):4541-5.

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