TAS-301|TAS301|193620-69-8|DC Chemicals

Cas No.:	193620-69-8
Chemical Name:	3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Synonyms:	TAS-301,TAS 301.TAS301
SMILES:	N1C2=C(C=CC=C2)/C(=C(\C2=CC=C(OC)C=C2)/C2=CC=C(OC)C=C2)/C1=O
Formula:	C₂₃H₁₉NO₃
M.Wt:	357.4
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF.
In Vivo:	TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2].
In Vitro:	TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2].

Cat. No.	Product name	Field of application
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DC8376	TAS-301	TAS-301 is an inhibitor of smooth muscle cell migration and proliferation.
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