TCS 359|cas 301305-73-7|DC Chemicals|Price|Buy

Cas No.:	301305-73-7
Chemical Name:	Benzo[b]thiophene-3-carboxamide,2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-
Synonyms:	TCS359; TCS-359
SMILES:	COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
Formula:	C₁₈H₂₀N₂O₄S
M.Wt:	360.43
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM.
Target:	IC50 Value: 42 nM [1] Target: Flt3
In Vitro:	TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1].
References:	[1]. Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6.

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