TUG-1375|CAS 2247372-59-2|FFA2/GPR43 agonist

Cas No.:	2247372-59-2
Chemical Name:	(2R,4R)-2-(2-Chlorophenyl)-3-(4-(3,5-dimethylisoxazol-4-yl)benzoyl)thiazolidine-4-carboxylic acid
Synonyms:	TUG1375;TUG 1375
SMILES:	O=C(N1[C@@H](C2=CC=CC=C2Cl)SC[C@H]1C(O)=O)C3=CC=C(C4=C(C)ON=C4C)C=C3
Formula:	C₂₂H₁₉ClN₂O₄S
M.Wt:	442.542
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].
Target:	pKi: 6.69 (FFA2)[1]
In Vitro:	TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1].
References:	[1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.

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