Talampanel|GYKI 53773|Provide by DC CHEM

Cas No.:	161832-65-1
Chemical Name:	1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
Synonyms:	Ampanel, Kinampa, Talampanel (INN), GYKI 53773, AC1L4UWP, AC1Q5KPR
SMILES:	C[C@@H]1CC2=C(C=C3OCOC3=C2)C(C4=CC=C(N)C=C4)=NN1C(C)=O
Formula:	C₁₉H₁₉N₃O₃
M.Wt:	337.372
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).
In Vivo:	Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2]
In Vitro:	Talampanel is a glutamate receptor inhibitor with anti-seizure activity.

Cat. No.	Product name	Field of application
DC8824	Traxoprodil	Traxoprodil is an NMDA ε 2 (NR2B) antagonist that has been studied as an alternative to serotonin selective reuptake inhibitors.
DC7863	Talampanel (GYKI 53773)	Talampanel is a novel anticonvulsant that acts as an allosteric inhibitor of the AMPA receptor.
DC8175	Rapastinel(GLYX-13)	Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site.
DC8307	QNZ46	QNZ is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
DC7226	Perampanel(E2007）	Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.
DC7989	PEPA	PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
DC11382	NYX-2925	NYX-2925 is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory.
DC7576	NVP-AAM077	NVP-AAM077 is a potent antagonist for NMDA receptors.
DC11406	NBQX	NBQX is a potent aminomethylphosphonic acid receptor (AMPAR) antagonist with an IC50 of 0.7 ± 0.1 μM.
DC7194	MDL 29951	MDL-29951 is a novel glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.

Talampanel (GYKI 53773)