Tenovin-3|cas 1011301-27-1|DC Chemicals|Price|Buy

Cas No.:	1011301-27-1
Chemical Name:	1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea
Synonyms:	Tenovin 3,Tenovin3
SMILES:	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N
Formula:	C₁₈H₂₁N₃Os
M.Wt:	327.44384
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

Cat. No.	Product name	Field of application
DC10851	PK11000	PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 by covalent cysteine modification, without compromising DNA binding.
DC9504	YH239-EE	YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent
DC7314	Tenovin-3	Tenovin-3 is a small molecule activator of p53 transcriptional activity.
DC8467	RO8994	RO8994 is a potent and selective spiroindolinone MDM2 inhibitor for cancer therapy.
DC8865	RG-7112	RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
DC10070	PRIMA-1MET(APR-246)	PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity.
DC9902	PRIMA-1	PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
DC9257	NSC59984	NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells.
DC10074	MX69	MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
DC8414	MI-77301 (SAR405838)	MI-77301 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.